Chest pain and difficulty breathing:

Sudden changes in breathing patterns and chest pain may indicate heart or respiratory problems and require immediate medical attention.

Increased frequency of headaches:
Recurring headaches or an increase in their intensity can be a sign of problems such as high blood pressure or even eye problems.

Change in color of urine and stool:
Changes in the color of urine and stool can indicate liver and kidney problems, or even digestive problems.

Skin changes:

Skin discoloration, unexplained spots, or even persistent itching can be signs of a medical problem, such as skin inflammation or allergies.

Joint and bone pain:
Persistent joint or bone pain may indicate a chronic infection or bone or joint disorder that warrants a thorough medical examination.

Change in appetite:
Frequent or increased appetite can be a sign of digestive problems or psychological problems.