Medicines

Some medications can cause leg cramps as a side effect. Diuretics (used to treat high blood pressure), statins (used to treat cholesterol), medications used to treat asthma, depression, and osteoporosis are some examples. Diuretics in particular can deplete the body of potassium and other electrolytes, increasing the risk of cramps.

Basic medical conditions
A variety of medical conditions can cause frequent leg pulling at night. For example:

Peripheral artery disease (PAD): Narrowing of the arteries can cause poor circulation, especially at rest, causing swelling.
Diabetes: Nerve damage (neuropathy) associated with diabetes can cause muscle spasms.
Hypothyroidism: Low thyroid hormone levels can cause muscle weakness and muscle cramps.
Restless legs syndrome (RLS): Although different from normal muscle spasms, this condition can cause discomfort in the legs, the urge to move, and sleep disturbances.
Prevention of leg pain at night
Stay hydrated
Drinking plenty of water throughout the day is essential for maintaining normal muscle function and preventing cramps. If you’re active, increasing your water intake is especially important, and you may benefit from electrolyte-enriched drinks.